We're for all- ALL are for us for the greater interest of Humanism-Truth-Facts-Friendship-Unity-Participation including Physico-Mental Sound Health  with Spirituality, enrichment through ''TOTAL HEALTH SOLUTION'' to a Well-furnished GOALofTruth alloted for all in real sense ;

Though Health is Wealth yet It has Physical-Mental-Spiritual & etc. BASICs to evaluate properly both Separately and Mixed Forms where so many troubles reflect periodically without notices & hidden causes are working always POSSIBLY with Latent Hints.

From wikipedia & other reliable sources (Poets, Writers, Thinkers, Researchers, Free Lancers, Philosophers, Theologists, Scientists, Orators, Sociologists and Photographers +Artists-Musicians & UN etc.) we can learn as follows :

plt6.jpgplt12.jpgthal sp.jpg

Platelet disorders & Global Scenerio :

Anemia  & Blood Transfusion :

Blood Cancer :

Bone Marrow & RBC Production :

Infectious Diseases :

Thalassemias are congenital+++ Haematological disorders characterized by decreased hemoglobin+++ production & others Physico-Neuro-immunologic abnormalities from many sources beyond present medical concept. Symptoms depend on the type and can vary from acute to chronic sufferings. Often there are so many anemic conditions based on categories (low red blood cells or hemoglobin & related irregularities found seen normally).[1] Anemia can result in feeling tired, uneasiness, attentionless and pale-dry looking. There may also be bone problems, an enlarged spleenyellowish skin, and  urine abnormal in real sense. Slow growth-order comparatively both in physical +mental stages in maximum cases of all children suffer by the same.

There are two main types, alpha thalassemia and beta. The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests. Diagnosis may occur before birth through prenatal testing.

Treatment for those with more severe disease often includes regular blood transfusionsiron chelation, and folic acid. Iron chelation may be done with deferoxaminedeferasirox or deferiprone. Occasionally, a bone marrow transplant may be an option if economic and prescription support done properly. Complications may include iron overload from the transfusions with resulting heart or liver diseaseinfections, and osteoporosis etc based on complexities occur individually. If the spleen becomes overly enlarged, surgical removal may be required because of limited therapeutic applications the sciences have. Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a combination of both.[10] Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea every day for a year had significantly higher hemoglobin levels, and it was a well-tolerated treatment for patients who did not respond well to blood transfusions.[11] Another hemoglobin-inducer includes thalidomide, although it has not been tested in a clinical setting. The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent and non-transfusion dependent patients [12]

As of 2015, thalassemia occurs in about 280 million people, with about 439,000 having severe disease.[13] It is most common among people of GreekItalianMiddle EasternSouth Asian, and African descent.[7] Males and females have similar rates of disease.[14] It resulted in 16,800 deaths in 2015, down from 36,000 deaths in 1990 by present medical support.[6][15] Those who have minor degrees of thalassemia, similar to those with sickle-cell trait, have some protection against malaria, explaining why they are more common in regions of the world where malaria exists.[16]


Signs and symptoms[edit]

A patient having thalassemia shows enlarged spleen.
  • Iron overload: People with thalassemia can get an overload of iron in their bodies, either from the disease itself or from frequent blood transfusions. Too much iron can result in damage to the heart, liver, and endocrine system, which includes glands that produce hormones that regulate processes throughout the body. The damage is characterized by excessive deposits of iron. Without adequate iron chelation therapy, almost all patients with beta-thalassemia accumulate potentially fatal iron levels.[17]
  • Infection: People with thalassemia have an increased risk of infection. This is especially true if the spleen has been removed.[18]
  • Bone deformities: Thalassemia can make the bone marrow expand, which causes bones to widen. This can result in abnormal bone structure, especially in the face and skull. Bone marrow expansion also makes bones thin and brittle, increasing the risk of broken bones.
  • Enlarged spleen: The spleen aids in fighting infection and filters unwanted material, such as old or damaged blood cells. Thalassemia is often accompanied by the destruction of a large number of red blood cells and the task of removing these cells causes the spleen to enlarge. Splenomegaly can make anemia worse, and it can reduce the life of transfused red blood cells. Severe enlargement of the spleen may necessitate its removal.
  • Slowed growth rates: anemia can cause the growth of a child to slow down. Puberty may also be delayed in children with thalassemia.
  • Heart problems: Diseases, such as congestive heart failure and abnormal heart rhythms, may be associated with severe thalassemia.


COMMENTS FROM Dr. P. C. Majumder (- Author. Writer, Humanist, Physician (Physico-Mental & Spiritual) and Cosmopolitan Researcher in favor of ALL-CREATION Universally RESIDE++++ in positive ways for universal UNITY & LOVE++++)  as follows: 




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